On Maj 25-28, 2016, the Annual meeting of International Society of Thrombosis and Haemostasis-SSC was held in Montpellier (France). The updated results of the PRO-RBDD project were presented as oral communications: “PRO-RBDD study: new insights on the minimal residual FXIII coagulant activity to prevent spontaneous major bleeding” during the FVIII, FIX and RCDs subcommittee and the FXIII and Fibrinogen subcommittee.